Citrinin-Induced Toxicity in F0 Male Wistar Rats: Clinico-Haematological and Serum Biochemical Alterations

Received: 29/08/2014 Revised: 14/09/2014 Accepted: 15/09/2014 Abstract The present study was planned to investigate the clinical and haemato-biochemical changes in F0 male Wistar rats fed with graded doses of citrinin (CIT). The animals were divided into four groups comprising 25 rats in each, viz., group I: 1ppm CIT; group II: 3ppm CIT; group III: 5ppm CIT; and group IV: 0 ppm CIT (control). After 10 weeks, rats were used to breed the female rats to get F1 generation. After successful mating, all the male rats were killed at the end of the study on day 105. Clinical signs, body weights and various haemato-biochemical parameters were estimated. The long-term dietary exposure to CIT in male rats resulted in anaemia, leucocytopenia due to lymphocytopenia and hepato-renal toxicity as evidenced by certain biochemical parameters.